Geoff Murphy, PhD

Geoff Murphy, PhD

Associate Director, Neuroscience Graduate Program

5037 BSRB

109 Zina Pitcher Place

Ann Arbor, MI 48109-2200

(734) 936-8926

murphyg@umich.edu

EDUCATION

1986–1990      B.A.; Neurobiology conferred 05/1990

                        University of California Berkeley College of Letters and Science

                        Interdepartmental Studies Program

                        Research Advisor: Mark R. Rosenzweig Ph.D. (Psychology)

1992–1998      Ph.D.; Neuroscience conferred 07/1998

                        University of California at Los Angeles School of Medicine

                        Interdepartmental Program for Neuroscience

                        Thesis Advisor: David L. Glanzman Ph.D.

 

POSTDOCTORAL TRAINING

1998–2003      University of California at Los Angeles School of Medicine

                        Departments of Neurobiology Psychiatry & Psychology

                        Supervisor: Alcino J. Silva Ph.D.

 

MILITARY SERVICE

1979–1983      United States Navy; Petty Officer 2nd Class; Active Duty

1983–1985      United States Navy; Petty Officer 2nd Class; Reserve

 

INDUSTRIAL APPOINTMENTS

1990–1992      Assistant Scientist

                        Department of Pharmacology

                        Shaman Pharmaceuticals San Carlos CA

 

ACADEMIC APPOINTMENTS

2003–2010      Assistant Professor Department of Molecular and Integrative Physiology

                        University of Michigan Medical School Ann Arbor Michigan

2003–2010      Research Assistant Professor Molecular & Behavioral Neuroscience Institute University of Michigan Ann Arbor Michigan

2010­–2017      Associate Professor Department of Molecular and Integrative Physiology

                        University of Michigan Medical School Ann Arbor Michigan

2010–2017      Research Associate Professor Molecular & Behavioral Neuroscience Institute

                        University of Michigan Ann Arbor Michigan

2017­–              Professor Department of Molecular and Integrative Physiology

                        University of Michigan Medical School Ann Arbor Michigan

2017–              Research Professor Molecular & Behavioral Neuroscience Institute

                        University of Michigan Ann Arbor Michigan

My current research interests are reflective of the journey and not a destination. Even as an undergraduate, I was interested in learning and memory and to this day I am still fascinated by the topic. Specifically, I am interested in how changes in intrinsic neuronal excitability contribute to memory formation, storage and retrieval. To this end I am interested in a class of proteins, known as voltage gated ion channels. These channels selectively permit charged ions to cross the cell membrane and therefore control a vast array of neuronal functions. My interest in these channels (specifically voltage-gated calcium channels) has in turn led me to investigate how altered ion channel dynamics and expression play a role in age-related cognitive decline. These studies have subsequently led me to the study of Alzheimer’s disease using genetically engineered mice that emulate specific Alzheimer’s disease pathologies. My interest in calcium channels has also extended to investigate their putative role in psychiatric diseases including bipolar disorder. I am also interested in how proteins that are associated with ion channels (so called auxiliary subunits) regulate channel function and neuronal excitability under normal conditions and disease states. Because a lot of my work relies on mice and mouse genetics I have also developed a strong interest in the neurobiological differences between inbred mouse strains and how these difference might be exploited to gain insights into polygenic diseases that manifest as mental illness. Finally, the University Michigan is such a wonderful place to participate in team science—as such my lab collaborates with a number of other labs whose research is focused on temporal lobe epilepsy, blood brain barrier dysfunction and axonal guidance. The journey continues.

1995    Individual National Research Service Award National Institute of Mental Health (Grant Number: F31 MH11136)

1997    UCLA Distinguished Scholar Award

1997    UCLA Dean’s Dissertation Year Fellowship

1999    Bank of America-Giannini Foundation Medical Research Fellowship Award

1999    Individual National Research Service Award National Institute on             Aging (Grant Number: F32 AGO5858)

2003    University of Michigan Neuroscience Scholar

2006    University of Michigan Neuroscience Program Outstanding Faculty Service Award

2008    National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award

2012    Teaching Award Endowment for the Basic Science

To address questions regarding how ion channels modulate neuronal function and ultimately behavioral output, my lab makes and uses transgenic mice that have been genetically engineered to either lack specific genes, over express specific gene products or produce gene products that have been functionally mutated. Using a multidisciplinary approach that combines aspects of modern molecular biology, behavioral neuroscience and electrophysiology, the lab is currently pursuing a number of broad-based research domains:

L-type voltage-gated calcium channels, CaV1.2 & CaV1.3
Potassium channel auxiliary subunits, KVβ1.1 & KVβ2
Voltage gated sodium channel Na V1.6

In addition, we have a number of active collaborations at the University of Michigan as well as at other institutions which include a number of translational projects that emphasize specific disease models:

Neurogenesis and Temporal Lobe Epilepsy (TLE)
Alzheimer Disease
Neurofibromatosis type I (NFI)
TBI and blood brain barrier function
Metabolic disease and cognitive function

https://sites.google.com/a/umich.edu/murphy-lab/research