Investigative Approaches

What makes neuroscience so unique at Michigan?

  • We are consistently ranked among the top 5 research institutions in the United States (QS World University Rankings for 2016)
  • We have a fully integrated health system
  • We are consistently ranked in the top 10 for NIH funding (Medical School)
  • We have a collaborative environment that boasts over 50 different Centers, Institutes and Core Facilities, hundreds of research areas, and are supported, in part, by 29 NIH training grants.

Here is a list of approaches applied across our research areas:

Electrophysiology-In vitro and in vivo analysis of spiking activity, synaptic plasticity, circuit behavior, patch clamp, voltage clamp, single channel recording, current clamp recording of network activity via multi electrode arrays in vivo and in vitro dialysis.

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Optogenetics and Live Imaging-learning, memory, behavior and sleep circuitry, confocal, multi-photon, total internal reflection microscopy, FRAP, and FRET

Gene Expression and Proteomics-mass spec, LC-MS-MS, crystal structure, NMR, affinity purification, protein microarrays

Genetics and Genomics-mutagenic analysis via transgenic and knock-out organisms, real-time-PCR, RT-PCR, SNP typing, gene chip expression analysis and microarrays, CHiP analysis, transcriptome

Cell & Cell Culture Systems- primary cultures of neurons and glia, embryonic stem cells, induced pluripotent cells, stem brain slice, neuroendocrine cells 

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Model Systems-Caenorhabditis elegans, Drosophilia, Xenopus, Zebrafish, Chick, Mouse, Rat

Behavioral-operant conditioning, Morris water maze, Pavlovian conditioning, rotarod, elevated plus maze, social defeat, light-dark box, home cage activity, object recognition/discrimination, active/passive avoidance, operant conditioning for drug reward, and conditioned place preference.

Cognitive-structural and functional MRI, diffusion-weighted MRI, Transcranial magnetic stimulation, PET with various ligands, SPECT, genetic testing, neuropsychological assessments, and behavioral testing. 

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