Sleep-dependent potentiation in the visual system is at odds with the Synaptic Homeostasis Hypothesis.

Associated faculty or student(s): Publication Date:
Friday, January 1, 2016
Abstract:

Two commentaries recently published in SLEEP came to very different conclusions regarding how data from a mouse model of sleep-dependent neural plasticity (orientation-specific response potentiation; OSRP) fit with the synaptic homeostasis hypothesis (SHY). To assess whether SHY offers an explanatory mechanism for OSRP, we present new data on how cortical neuron firing rates are modulated as a function of novel sensory experience and subsequent sleep in this model system.

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