Sebastian Werneburg, Ph.D.
Research in the Werneburg Lab focuses on understanding neuron-glia interactions and how these contribute to neuroinflammation and the de- and regeneration of neural circuits in neurological disorders. In particular, we are interested in the crosstalk between microglia, synapses, and inflammatory signaling pathways and how this communication affects circuit function in the visual system in mouse models of Multiple Sclerosis and related neurodegenerative diseases. The goal of our research is to unravel new cellular and molecular targets and develop strategies for therapeutic interventions that can halt progressive circuit degeneration or improve recovery – processes that are only insufficiently targeted by available disease-modifying therapies. To address these questions, the lab uses cutting-edge molecular, genetic, and omic approaches combined with high-resolution static and live confocal imaging and animal behavior testing.
Keywords: neuron-glia interactions, microglia, synapses, neural circuits, visual system, degeneration, regeneration, stress signaling, demyelinating disease, Multiple Sclerosis, neuroimmunology, complement signaling, neuronal activity alterations, and animal behavior.