Novel application of a Radial Water Tread maze can distinguish cognitive deficits in mice with traumatic brain injury

Associated faculty or student(s): Publication Date:
Thursday, February 15, 2018
Abstract:

Abstract

Introduction: The use of forced-swim, rat-validated cognition tests in mouse models of traumatic brain injury (TBI) raises methodological concerns; such models are vulnerable to a number of confounding factors including impaired motor function and stress-induced non-compliance (failure to swim). This study evaluated the ability of a Radial Water Tread (RWT) maze, designed specifically for mice, that requires no swimming to distinguish mice with controlled cortical impact (CCI) induced TBI and Sham controls.

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